The paper reviews empirical problems in structural geology and theoretical ideas on the regularities in regional shift zones of the Earth's crust. The article considers physico-mechanical and mechano-chemical conditions for destruction of mineral environments, their forced structurization and mechano-chemical activation of solid phase reactions, and mineral alterations in a strained shift setting. For the regional shift zones of crust the following models have been developed: 1) four-element model of structure, independent of spatial and time coordinates and scales of occurrence; 2) classification of rock associations of tectonites including the groups of compact tectonic mixtites and tectonic shales (blastomilonites) together with loose dynamoclastites; 3) regularities of stress-metamorphism with separation of destruction zones (epizones), cataclastic and plastic flow (meso- and catazone, respectively); 4) shift flow of mineral masses and separational-seggregational mechanism of rock-, ore-, and structure generation. General conception of the shift stress-structure generation in lithosphere are discussed: invariance in the structure of shift zones, volumetric of structure-substance alteration under the influence of ultimate dynamic stress, high speed of transformations based on shift flow of mineral masses and destructive-constructive character of structurization.